Relative lack of β1‐subunit‐mediated regulation of BK Ca in cremaster arteriolar smooth muscle
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چکیده
منابع مشابه
Complex interactions of NO/cGMP/PKG systems on Ca signaling in afferent arteriolar vascular smooth muscle
Fellner SK, Arendshorst WJ. Complex interactions of NO/cGMP/ PKG systems on Ca signaling in afferent arteriolar vascular smooth muscle. Am J Physiol Heart Circ Physiol 298: H144–H151, 2010. First published October 30, 2009; doi:10.1152/ajpheart.00485.2009.—Little is known about the effects of nitric oxide (NO) and the cyclic GMP (cGMP)/protein kinase G (PKG) system on Ca signaling in vascular s...
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BACKGROUND Magnolol, a compound isolated from the cortex of Magnolia officinalis, has been found to possess anti-allergic and anti-asthmatic activity. METHODS The effect of magnolol on ionic currents was studied in cultured smooth muscle cells of human trachea with the aid of the patch clamp technique. RESULTS In whole cell current recordings magnolol reversibly increased the amplitude of K...
متن کاملAbolition of arteriolar dilation but not constriction to histamine in cremaster muscle of eNOS-/- mice.
Histamine increases the permeability of capillaries and venules but little is known of its precapillary actions on the control of tissue perfusion. Using gene ablation and pharmacological interventions, we tested whether histamine could increase muscle blood flow through stimulating nitric oxide (NO) release from microvascular endothelium. Vasomotor responses to topical histamine were investiga...
متن کامل[Enhanced BK(Ca) single-channel activities in cerebrovascular smooth muscle cells of simulated microgravity rats.].
The aim of the present study was to investigate the changes in single-channel currents of large conductance calcium-activated potassium channels (BK(Ca) channels) in cerebral vascular smooth muscle cells (VSMCs) of rats after 1-week simulated microgravity. Sprague-Dawley rats were subjected to tail-suspension (SUS) to simulate cardiovascular deconditioning due to microgravity. Cytosolic calcium...
متن کاملVoltage dependence of the coupling of Ca(2+) sparks to BK(Ca) channels in urinary bladder smooth muscle.
Large-conductance Ca(2+)-dependent K(+) (BK(Ca)) channels play a critical role in regulating urinary bladder smooth muscle (UBSM) excitability and contractility. Measurements of BK(Ca) currents and intracellular Ca(2+) revealed that BK(Ca) currents are activated by Ca(2+) release events (Ca(2+) sparks) from ryanodine receptors (RyRs) in the sarcoplasmic reticulum. The goals of this project were...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2009
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.23.1_supplement.627.10